Characterizing the In Utero Phenome of the Chiari II Malformation-A Network Medicine Approach, Using Fetal MRI.

ABSTRACT:

Objective

To apply a network medicine-based approach to analyze the phenome of the prenatal fetal MRI and biometric findings in the Chiari II malformation (CM II) to detect specific patterns and co-occurrences.

Method

A single-center retrospective review of fetal MRI scans obtained in fetuses with CM II was performed. Co-occurrence analysis was utilized to generate a phenotypic comorbidity matrix and visualized by Gephi software. Traditional univariate regression and geometric thin-plate spline methodology were used to elucidate the mechanisms underlying the relationships between morphometric measurements and geometric landmarks of the spine, skull, and brain deformations.

Results

The CM II phenome consists of 35 nodes interconnected by 979 edges with a density of 0.8

SUBMITTER: Shi H 

PROVIDER: S-EPMC11893518 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature