Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.

ABSTRACT:

Study objectives

Repeated exposure to familiar visual sequences drives experience-dependent and sequence-specific plasticity in mouse primary visual cortex (V1). Prior work demonstrated a critical role for sleep in consolidating a related but mechanistically distinct form of experience-dependent plasticity in V1. Here, we assessed the role of sleep in consolidation of spatiotemporal sequence learning (sequence plasticity) in mouse V1.

Methods

Visually evoked potentials were recorded in awake, head-fixed mice viewing sequences of four visual stimuli. Each sequence was presented 200 times per session, across multiple sessions, to drive plasticity. The effects of sleep consolidation time and sleep deprivation on plasticity were assessed.

Results

Sequence plasticity occur

SUBMITTER: Hosamane NS 

PROVIDER: S-EPMC11893538 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature