Physiological and psychological stress reactivity in narcolepsy type 1.

ABSTRACT:

Study objectives

Narcolepsy type 1 (NT1) is a chronic sleep-wake disorder, characterized by a loss of hypocretin production. Unexpectedly, in postmortem tissue of people with NT1, there is a loss of corticotrophin-releasing hormone (CRH) in the paraventricular nucleus. CRH is known as an activator of the hypothalamic-pituitary-adrenal axis in response to stress. This activation results in the release of the stress hormones adrenocorticotropic hormone (ACTH) and cortisol. We hypothesize an altered physiological and psychological stress response in NT1.

Methods

Participants were people with NT1 (n = 14) and matched healthy controls (n = 12). The Trier Social Stress Test for Groups (TSST-G), a validated socially evaluated stress test in controlled settings, induced acute stress

SUBMITTER: Vringer M 

PROVIDER: S-EPMC11893539 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature