Behavioral and neural effects of temporoparietal high-definition transcranial direct current stimulation in logopenic variant primary progressive aphasia: a preliminary study.

ABSTRACT:

Background

High-definition-tDCS (HD-tDCS) is a recent technology that allows for localized cortical stimulation, but has not yet been investigated as an augmentative therapy while targeting the left temporoparietal cortex in logopenic variant PPA (lvPPA). The changes in neuronal oscillatory patterns and resting-state functional connectivity in response to HD-tDCS also remains poorly understood.

Objective

We sought to investigate the effects of HD-tDCS with phonologic-based language training on language, cognition, and resting-state functional connectivity in lvPPA.

Methods

We used a double-blind, within-subject, sham-controlled crossover design with a 4-month between-treatment period in four participants with lvPPA. Participants completed language, cognitive assessmen

SUBMITTER: Granadillo ED 

PROVIDER: S-EPMC11893574 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature