Baicalein as a potent antifungal agent against <i>Candida albicans</i>: synergy with fluconazole and sustainable production through probiotic-mediated bioconversion.

ABSTRACT: Fungal infections, particularly those caused by Candida albicans, represent a significant global health concern, with drug resistance and biofilm formation posing considerable challenges to effective treatment. Baicalein, a flavonoid derived from baicalin found in Scutellaria baicalensis, has demonstrated considerable antifungal efficacy. Moreover, the combination of baicalein and fluconazole demonstrated a notable synergistic effect. Given the restricted natural accessibility of baicalein, Lactobacillus rhamnosus has been identified as a microbial agent capable of converting baicalin to baicalein via whole-cell catalysis. This process has been shown to achieve a molar yield of 66% at a substrate concentration of 4 g/L under optimized conditions. In addition to the ant

SUBMITTER: Zhai H 

PROVIDER: S-EPMC11893618 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature