Genetic overlap between idiopathic scoliosis and schizophrenia in the general population.

ABSTRACT:

Introduction

Adolescent idiopathic scoliosis (AIS) and schizophrenia (SCZ) are two distinct conditions with poorly understood aetiologies that both emerge in otherwise healthy young adolescents. One rare genetic condition associated with both phenotypic outcomes is the 22q11.2 deletion (22q11DS). This microdeletion, encompassing 47 genes, occurs in approximately 1 in 2,148 live births and confers a 20-fold higher risk for both AIS and schizophrenia compared to the general population. In the general population (non-22q11DS carriers), AIS and SCZ have also been reported to be related and genetic studies suggest the involvement of genetic variants implicated in the central nervous functioning. In this study, our objective was to further investigate genetic overlaps between these condi

SUBMITTER: de Reuver S 

PROVIDER: S-EPMC11893639 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature