Integrative metabolo-genomics suggests a biosynthetic pathway for tetrangulol in Streptomyces sp. KL110A.

ABSTRACT: Natural products (NPs) of microbial origin are highly valued for their diverse bioactive properties. Among bacteria, Streptomyces stands out as a prolific source of NPs with applications in medicine and agriculture. Recent advances in metabolomics, and bioinformatics as well as the abundance of genomic data have revolutionized the study of NPs, enabling the rapid connection of biosynthetic pathways and metabolites. However, discovering novel compounds from large pools of genomes and strains is cumbersome. Metabolo-genomics approaches are promising strategies that can save time and resources at initial stages of the natural product discovery pipeline by rapidly linking molecules and their biosynthetic genes. Here, we present genomic characterization and metabolomic profiling of Streptomyces

SUBMITTER: Trejo-Alarcon LM 

PROVIDER: S-EPMC11893679 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature