Investigation of the Blood Microbiome in Horses With Fever of Unknown Origin.

ABSTRACT:

Background

Fever of unknown origin (FUO) without a respiratory component is a frequent clinical presentation in horses. Multiple pathogens, both tick-borne and enteric, can be involved as etiologic agents. An additional potential mechanism is intestinal barrier dysfunction.

Objectives

This case-control study aimed to detect and associate microbial taxa in blood with disease state.

Study design

Areas known for a high prevalence of tick-borne diseases in humans were chosen to survey horses with FUO, which was defined as fever of 101.5°F or higher with no signs of respiratory illness or other recognisable diseases. Blood samples and clinical parameters were obtained from 52 FUO cases and also from matched controls from the same farms. An additional 23 febrile horses with

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11893731 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature