Electrochemical cobalt-catalyzed semi-deuteration of alkynes to access deuterated Z-alkenes.

ABSTRACT: Deuterium labeling has found extensive applications across various research fields, including organic synthesis, drug design, and molecular imaging. Electrocatalytic semi-hydrogenation of alkynes offers a viable route for the synthesis of Z-alkenes, yet it falls short in achieving the semi-deuteration of these compounds. In this study, we report an electrochemical cobalt-catalyzed transfer deuteration reaction that proficiently accomplishes the semi-deuteration of alkynes, yielding Z-configuration deuterated alkene products. This reaction utilizes cost-effective cobalt salts as catalysts and employs D₂O and AcOD (acetic acid-d) as economical and efficient deuterium sources, underscoring its practicality and feasibility. The reaction demonstrates a broad alkyne substrate scope, h

SUBMITTER: Feng WJ 

PROVIDER: S-EPMC11893763 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature