SLAMF7 (CD319) on activated CD8⁺ T cells transduces environmental cues to initiate cytotoxic effector cell responses.

ABSTRACT: CD8⁺ T-cell responses are meticulously orchestrated processes regulated by intercellular receptor:ligand interactions. These interactions critically control the dynamics of CD8⁺ T-cell populations that is crucial to overcome threats such as viral infections or cancer. Yet, the mechanisms governing these dynamics remain incompletely elucidated. Here, we identified a hitherto unknown T-cell referred function of the self-ligating surface receptor SLAMF7 (CD319) on CD8⁺ T cells during initiation of cytotoxic T-cell responses. According to its cytotoxicity related expression on T effector cells, we found that CD8⁺ T cells could utilize SLAMF7 to transduce environmental cues into cellular interactions and information exchange. Indeed, SLAMF7 facilitate

SUBMITTER: Lingel H 

PROVIDER: S-EPMC11893764 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature