GelMA as scaffold material for epithelial cells to emulate the small intestinal microenvironment.

ABSTRACT: Host-microbe interactions in the intestine play a significant role in health and disease. Novel scaffolds for host cells, capable of potentially supporting these intricate interactions, are necessary to improve our current systems for mimicking host-microbiota interplay in vitro/ex vivo. In this research paper, we study the application of gelatin methacrylamide (GelMA) as scaffold material for intestinal epithelial cells in terms of permeability, mechanical strength, and biocompatibility. We investigated whether the degree of substitution (DS) of GelMA influences the permeability and found that both high and low DS GelMA show sufficient permeability of biorelevant transport markers. Additionally, we researched epithelial cell adherence and viability, as well as mechanical characteristics o

SUBMITTER: Roegiers I 

PROVIDER: S-EPMC11893807 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature