Effects and potential pathways of goose astrovirus infection on gosling hepatic lipid metabolism.

ABSTRACT:

Introduction

The adverse effects of goose astrovirus (GoAstV) on avian growth and health have been widely reported previously, while the stress reactions and corresponding mechanism of gosling liver responding to GoAstV infection remain not entirely clear.

Methods

One-day-old goslings inoculated subcutaneously with 2 × 10^-6 TCID₅₀ of GoAstV were employed as an experimental model, and the potential effects and pathways of GoAstV infection on gosling liver functions were investigated by combining the morphological, biochemical and RNA sequencing (RNA-seq) techniques.

Results

Structural and functional impairments were found in gosling livers post the virus infection, as characterized by the histological alterations in liver index and morphology of h

SUBMITTER: Yin C 

PROVIDER: S-EPMC11893818 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature