HLA allele and haplotype frequencies of eight Indian populations based on 130,518 registered stem cell donors.

ABSTRACT:

Introduction

In hematopoietic stem cell transplantation, optimal results are achieved when donors and patients are matched regarding their human leukocyte antigen (HLA) genes. Population-specific HLA allele and haplotype frequency distributions determine the probabilities to find matched donors in a stem cell donor registry of given size and ethnic composition.

Methods

To evaluate the needs of Indian patients with regard to future donor recruitment, we analyzed a large data set of n=130,518 potential stem cell donors registered with DKMS-BMST, a Bangalore-based donor registry with nationwide donor recruitment activities. We defined 8 subpopulations by native language and state of origin of both parents. The subpopulations comprised four samples belonging to the Dravid

SUBMITTER: Solloch UV 

PROVIDER: S-EPMC11893841 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature