Cerebrospinal fluid profiles of targeted metabolomics on neurotransmitters in patients with post-neurosurgical bacterial meningitis.

ABSTRACT:

Background

Post-neurosurgical bacterial meningitis (PNBM) is a severe complication in patients receiving neurosurgical treatments. Pathogens and neuroinflammation have been reported to influence metabolites in the microenvironment of the central nervous system. However, information about the relationship between neurotransmitter levels and PNBM is still limited. In this study, we aimed to investigate the diagnostic potential of neurotransmitters for PNBM in the patients with stroke.

Methods

In this study, a total of 66 stroke patients were recruited. Among them, 40 patients were complicated with PNBM. We profiled cerebrospinal fluid (CSF) levels of neurotransmitter precursors and metabolites using the targeted metabolomics method, which contained 26 precursors and metabolite

SUBMITTER: Mei Z 

PROVIDER: S-EPMC11893869 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature