Drug-Related Hypertension: A Disproportionality Analysis Leveraging the FDA Adverse Event Reporting System.

ABSTRACT: Hypertension exerts a significant global disease burden, adversely affecting the well-being of billions. Alarmingly, drug-related hypertension remains an area that has not been comprehensively investigated. Therefore, this study is designed to utilize the adverse event reports (AERs) from the US Food and Drug Administration's Adverse Event Reporting System (FAERS) to more comprehensively identify drugs that may potentially lead to hypertension. Specifically, a total of 207 233 AERs were extracted from FAERS, spanning the time period from 2004 to 2024. Based on these reports, this study presented the top 40 drugs most frequently reported to be associated with post-administration hypertension in different genders. Furthermore, we employed four disproportionality analysis methods, including R

SUBMITTER: Zhu H 

PROVIDER: S-EPMC11894037 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature