Mechanism of skull base osteoradionecrosis explored through laboratory assessment with propensity score-matched analysis.

ABSTRACT: Skull base osteoradionecrosis (sbORN) is a severe complication of radiotherapy (RT) in patients with nasopharyngeal carcinoma (NPC) that can severely affect quality of life (QOL) and may even be life-threatening. The etiology and pathogenesis of sbORN remain largely unknown or uncertain. Therefore, this study aimed to identify potential risk factors for sbORN by analyzing the laboratory assessments of patients to enable early clinical interventions. This retrospective case-control study reviewed NPC patients who were pathologically diagnosed with sbORN after primary radical radiotherapy. These patients were matched 1:1 with propensity scores for patients without sbORN at our center. The impact of laboratory examination indexes on sbORN occurrence was assessed using both univariate and mult

SUBMITTER: Li J 

PROVIDER: S-EPMC11894041 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature