Spatially fractionated minibeam radiation delivered at clinically feasible dose rates induces transient vascular permeability.

ABSTRACT: Microbeam Radiation Therapy is a preclinical form of spatially fractionated radiation therapy that utilizes synchrotron X-rays to deliver highly heterogeneous dose distributions at a micrometric scale. This radiation scheme has been shown to facilitate the induction of controlled and reversible vascular permeability, enhancing treatment efficacy of systemic therapeutic agents. Despite the promising preclinical results, translating microbeam SFRT to the clinic has been hindered by a reliance on synchrotron sources that operate at dose rates orders of magnitude greater than what is possible with clinical machines. Without rapid dose delivery, the microbeam geometry is susceptible to blurring due to physiologic motion when delivered at clinical dose rates. Therefore, larger beam widths, space

SUBMITTER: Fazzari J 

PROVIDER: S-EPMC11894116 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature