Paper battery powered iontophoresis microneedles patch for hypertrophic scar treatment.

ABSTRACT: Hypertrophic scar (HS) is a plaque fibrous and indurated dermal lesion that may cause physical, psychological, and cosmetic challenges for patients. Intralesional injection of triamcinolone acetonide (TA) is commonly used in clinical practice, which cause unbearable pain and uneven drug delivery within HS tissue. Herein, we developed a paper battery powered iontophoresis-driven microneedles patch (PBIMNP) for self-management of HS. The high integration of PBIMNP was achieved by incorporating a paper battery as the power source for iontophoresis. The transdermal drug delivery strategy of PBIMNP combined microneedles and iontophoresis techniques, involving "pressing and poking, phase transformation, and diffusion and iontophoresis", which can actively deliver 90.19% drug into the HS tissue w

SUBMITTER: Gao J 

PROVIDER: S-EPMC11894194 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature