Interaction of integrin α_vβ₃ and fibronectin under fluid shear forces: implications for tumor cell adhesion and migration.

ABSTRACT: The interaction between integrin α_vβ₃ and fibronectin enables tumor cell adherence to endothelial layers under diverse hydrodynamic blood flow conditions, particularly in low shear stress regions. Understanding the mechanical binding characteristics between integrin α_vβ₃ and fibronectin under different hydrodynamic environments can provide insights into tumor cell invasion and proliferation. Here, the adhesive behavior of fibronectin-functionalized microspheres on integrin α_vβ₃-coated substrates under various wall fluid shear forces (0.1-0.7 dyn/cm²) was assessed using a parallel plate flow chamber system. The bond lifetimes of integrin α_vβ₃-fibronectin initially increased and then decreased,

SUBMITTER: Zhuo P 

PROVIDER: S-EPMC11894259 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature