TET1 participates in oxaliplatin-induced neuropathic pain by regulating microRNA-30b/Nav1.6.

ABSTRACT: Chemotherapy-induced neuropathic pain poses significant clinical challenges and severely impacts patient quality of life. Sodium ion channels are crucial in regulating neuronal excitability and pain. Our research indicates that the microRNA-30b (miR-30b) in rat dorsal root ganglia (DRG) contributes to chemotherapy-induced neuropathic pain by regulating the Nav1.6 protein. Additionally, ten-eleven translocation methylcytosine dioxygenase 1 (TET1) plays a crucial role in pain generation by altering gene expression. We established a chemotherapy-induced neuropathy model using intraperitoneal oxaliplatin (OXA) injections and measured TET1 and Nav1.6 protein in the DRG. Using lentivirus and Tet1^flox/flox mice, we modulated TET1 expression and assessed pain behaviors, DRG neuronal exc

SUBMITTER: Zhao S 

PROVIDER: S-EPMC11894311 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature