Altered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia.

ABSTRACT:

Background

Dysfunctional allostatic-interoception, altered processing of bodily signals in response to environmental demands, occurs in behavioural-variant frontotemporal dementia (bvFTD) patients. Previous research has not investigated the dynamic nature of interoception using methods like intrinsic neural timescales. We hypothesised that longer intrinsic neural timescales of interoception would occur in bvFTD patients, evidencing dysfunctional allostatic-interoception.

Methods

One-hundred and twelve participants (31 bvFTD patients, 35 Alzheimer's disease patients, AD and 46 healthy controls) completed a well-validated task measuring cardiac-interoception and exteroception. Simultaneous EEG and ECG were recorded. Intrinsic neural timescales were measured via the autocorrela

SUBMITTER: Hazelton JL 

PROVIDER: S-EPMC11894334 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature