Investigating Metrics of Discrete-Individual Repeatability of the Stress Response.

ABSTRACT: There is currently no consensus on the most biologically meaningful way to calculate discrete-individual repeatability of stress response curves. In the current study, we compared three metrics of discrete-individual repeatability that incorporate the whole stress response curve: profile repeatability, Kullback-Leibler (KL) divergence, and hypothalamic-pituitary-adrenal (HPA) flexibility. As part of this work, we present a new R package for computing profile repeatability, "profrep." Using three datasets (one synthetic and two corticosterone datasets from live birds), our objectives were (1) to compare how these metrics correlate with one another and (2) to determine how representative repeatability scores of fewer replicates were to the "consensus" score (i.e., the score of the full datas

SUBMITTER: Beattie UK 

PROVIDER: S-EPMC11894371 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature