Use of surrogate endpoints in health technology assessment: a review of selected NICE technology appraisals in oncology.

ABSTRACT:

Objectives

Surrogate endpoints, used to substitute for and predict final clinical outcomes, are increasingly being used to support submissions to health technology assessment agencies. The increase in the use of surrogate endpoints has been accompanied by literature describing the frameworks and statistical methods to ensure their robust validation. The aim of this review was to assess how surrogate endpoints have recently been used in oncology technology appraisals by the National Institute for Health and Care Excellence (NICE) in England and Wales.

Methods

This article identifies technology appraisals in oncology published by NICE between February 2022 and May 2023. Data are extracted on the use and validation of surrogate endpoints including purpose, evidence base, and me

SUBMITTER: Wheaton L 

PROVIDER: S-EPMC11894387 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature