The Effect of Heparin on Bone Metabolism and Orthodontic Tooth Movement in Rats.

ABSTRACT:

Objectives

Various attempts have been made to increase the rate of orthodontic tooth movement (OTM). The aim of this study was to determine the effect of different doses of heparin on OTM and paraclinical factors related to bone metabolism in rats.

Methods and materials

A total of 24 Sprague-Dawley rats were randomly divided into three groups of 8 animals each and injected with 0 (control), 3000, and 6000 U/Kg/d heparin sulfate for 4 weeks. Radiographs were obtained at the initiation and at the end of the study period. Orthodontic forces were applied on Day 14 and continued for the next 2 weeks, after which, OTM, optical density, parathyroid hormone (PTH) level, and histologic variables were assessed for each rat. The latter was performed on hematoxylin/eosin-stained section

SUBMITTER: Salari B 

PROVIDER: S-EPMC11894433 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature