Second-Line Medications for Women Aged 10 to 50 Years With Idiopathic Generalized Epilepsy.

ABSTRACT:

Importance

Women with idiopathic generalized epilepsy (IGE) face challenges in treatment due to limited options that are both effective and safe.

Objective

To evaluate the effectiveness and safety of substitution monotherapy vs add-on therapy as second-line options for women who might become pregnant with IGE after failure of first-line antiseizure medications (ASMs) other than valproic acid.

Design, setting, and participants

Multicenter retrospective comparative effectiveness cohort study at 18 primary, secondary, and tertiary adult and children epilepsy centers across 4 countries, analyzing data from 1995 to 2023. Participants were women aged 10 to 50 years diagnosed with IGE who were prescribed a second line of ASM.

Main outcomes and measures

Treatment failu

SUBMITTER: Cerulli Irelli E 

PROVIDER: S-EPMC11894492 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature