Universal vs Targeted Chlorhexidine Bathing and Nasal Decolonization in Hospitalized Patients.

ABSTRACT:

Importance

The ABATE Infection trial investigated the effects of universal bacterial decolonization with chlorhexidine for patients in non-intensive care unit settings to reduce hospital-onset bacteremia and fungemia (HOB) events. Among patients with medical devices (central venous catheters, midline catheters, and lumbar drains), universal decolonization (UD) resulted in a significant and meaningful reduction in bacteremia compared with the standard of care (SOC), but cost-effectiveness is unclear.

Objective

To examine the cost-effectiveness of universal and targeted bathing strategies compared with SOC in general medical and surgical units.

Design, setting, and participants

A decision analytic model was constructed from June 1, 2021, to May 31, 2024, to simulate the

SUBMITTER: James LP 

PROVIDER: S-EPMC11894500 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature