Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis.

ABSTRACT: Currently, the clinical outcomes of patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) with baseline brain metastasis receiving first- and second-generation EGFR-tyrosine kinase inhibitors (TKIs) are not clear. The present study aimed to assess the clinical outcomes of patients with EGFR-mutated NSCLC with baseline brain metastasis who received first-line first- and second-generation EGFR-TKIs. In the present study, a retrospective analysis of clinical charts was performed to investigate first- and second-generation EGFR-TKIs in patients with EGFR-mutated NSCLC with baseline brain metastasis. Data from 197 patients with EGFR-mutated NSCLC with baseline brain metastasis who received first-line gefitinib, erlotinib or afatini

SUBMITTER: Hsu CC 

PROVIDER: S-EPMC11894514 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature