Integrated myocardial flow reserve (iMFR) assessment: optimized PET blood flow quantification for diagnosis of coronary artery disease.

ABSTRACT:

Purpose

Distinguishing obstructive epicardial coronary artery disease (CAD) from microvascular dysfunction and diffuse atherosclerosis would be of immense benefit clinically. However, quantitative measures of absolute myocardial blood flow (MBF) integrate the effects of focal epicardial stenosis, diffuse atherosclerosis, and microvascular dysfunction. In this study, MFR and relative perfusion quantification were combined to create integrated MFR (iMFR) which was evaluated using data from a large clinical registry and an international multi-center trial and validated against invasive coronary angiography (ICA).

Methods

This study included 1,044 clinical patients referred for ⁸²Rb rest/stress positron emission tomography myocardial perfusion imaging and ICA, along w

SUBMITTER: Poitrasson-Riviere A 

PROVIDER: S-EPMC11894525 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature