Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus.

ABSTRACT:

Introduction

Systemic lupus erythematosus (SLE) is characterized by dysregulated humoral immunity, leading to the generation of autoreactive B cells that can differentiate both within and outside of lymph node (LN) follicles.

Methods

Here, we employed spatial transcriptomics and multiplex imaging to investigate the follicular immune landscaping and the in situ transcriptomic profile in LNs from SLE individuals.

Results

Our spatial transcriptomic analysis revealed robust type I IFN and plasma cell signatures in SLE compared to reactive, control follicles. Cell deconvolution revealed that follicular T cell subsets are mainly affected by the type I IFN fingerprint of SLE follicles. Dysregulation of T_FH differentiation was documented by i) the significan

SUBMITTER: Georgakis S 

PROVIDER: S-EPMC11894538 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature