A comprehensive analysis of the prognostic value, expression characteristics and immune correlation of MKI67 in cancers.

ABSTRACT:

Background

nuclear-associated antigen Ki67 (Ki67) emerges as a clinically practical biomarker for proliferation assessment among many cancer types. However, the definite prognostic value of Ki67 against a specific cancer type has remained vague. This study aims to perform a comprehensive pan-cancer analysis of the prognosis value of Ki67 across various cancer types.

Methods

This study explored the expression, prognostic value, and tumor-infiltrating immune of MKI67 in the TCGA database by pan-cancer, and then performed immunohistochemical, correlation analysis and prognostic analysis using 10028 patients of the top 10 cancer patients in China we collected. The correlation between MKI67 expression and survival outcome, clinical features, MSI, TMB, and tumor-infiltrating immun

SUBMITTER: Pan X 

PROVIDER: S-EPMC11894575 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature