Imaging markers of cerebral small vessel disease are associated with Alzheimer's disease: a systematic review and meta-analysis.

ABSTRACT:

Objective

This study aims to assess the correlation between cerebral small vessel disease (CSVD) imaging markers and the risk of Alzheimer's disease (AD) through a systematic review and meta-analysis.

Methods

In July 2024, two researchers independently conducted a thorough literature search across databases such as PubMed, Embase, Web of Science, and the Cochrane Library. The selected studies investigated the correlations between white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), lacunar infarction (LI), and enlarged perivascular spaces (EPVS) and the risk of AD. The Newcastle-Ottawa Scale (NOS) was employed to assess the risk of bias in the included cohort and case-control studies.

Results

A total of 6,487 articles were identified, with 15 articles me

SUBMITTER: Wu Q 

PROVIDER: S-EPMC11894735 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature