Subcutaneous Implantation of Open Microwell Islet Delivery Devices in Pigs.

ABSTRACT:

Background

Intraportal pancreatic islet transplantation is a treatment option for patients with severe beta cell failure and unstable glycemic control. However, this procedure is associated with loss of beta cells after intrahepatic transplantation. Islet delivery devices (IDDs) implanted at extrahepatic sites may support engraftment and improve survival of pancreatic islets. We assessed the surgical feasibility, tolerability and safety of implantation of open microwell devices at subcutaneous sites with varying friction in pigs.

Methods

Open, non-immunoisolating microwell islet delivery devices were made from polyvinylidene fluoride (PVDF). Empty (n = 26) and islet-seeded devices (n = 8) were implanted subcutaneously in 6 immunocompetent pigs in low-friction sites (abdomen

SUBMITTER: Tol MC 

PROVIDER: S-EPMC11894865 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature