Increased Systemic Immune-Inflammation Index as a Novel Indicator of Alzheimer's Disease Severity.

ABSTRACT:

Introduction

Inflammatory processes and neurodegeneration are common features of Alzheimer's disease (AD). The systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are easily accessible, cost-effective prognostic indicators of inflammation status. We assessed the diagnostic value of SII and compared the efficacies of NLR, PLR, and SII in predicting AD severity.

Materials and methods

Between January 2021 and December 2022, this prospective, cross-sectional clinical study included 175 patients with AD and 61 controls. SII, NLR, and PLR were calculated.

Results

Age, white blood cell and lymphocyte counts, and NLR and PLR values were significantly different between the patient and control groups (P <

SUBMITTER: Algul FE 

PROVIDER: S-EPMC11894901 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature