Longitudinal Investigation of Brain and Spinal Cord Pericytes After Inducible PDGFRβ⁺ Cell Ablation in Adult Mice.

ABSTRACT: Central nervous system (CNS) pericytes play crucial roles in vascular development and blood-brain barrier maturation during prenatal development, as well as in regulating cerebral blood flow in adults. They have also been implicated in the pathogenesis of numerous neurological disorders. However, the behavior of pericytes in the adult brain after injury remains poorly understood, partly due to limitations in existing pericyte ablation models. To investigate pericyte responses following acute ablation and characterize a novel rodent model for pericyte research, we developed a tamoxifen-inducible PDGFRβ⁺ cell ablation model by crossing PDGFRβ-P2A-CreER^T2 and Rosa26-DTA176 transgenic mouse lines. Using this model, we studied the effects of different tamoxifen doses and c

SUBMITTER: Atak D 

PROVIDER: S-EPMC11894923 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature