Comparison of lung disorders following intratracheal instillation of polystyrene microplastics with different surface functional groups.

ABSTRACT:

Objectives

Microplastics have been detected in the atmosphere, raising concerns about their impact on the lungs. There have been reports on the effects of surface functional groups in evaluating the physicochemical properties of microplastics, but no reports have evaluated their chronic effects. We performed intratracheal instillation in rats to evaluate the acute and chronic effects on the lungs of microplastics with different surface functional groups.

Methods

Unmodified, NH2-modified, and COOH-modified polystyrene particles with a particle size of 1 μm were intratracheally instilled into the lungs of rats. Rats were dissected at 3 days, 1 week, 1 month, 3 months, and 6 months after exposure to analyze inflammatory cells and lung injury factors in bronchoalveolar lavage fl

SUBMITTER: Tomonaga T 

PROVIDER: S-EPMC11894927 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature