HLA-E-restricted Hantaan virus-specific CD8⁺ T cell responses enhance the control of infection in hemorrhagic fever with renal syndrome.

ABSTRACT: Infection with the Hantaan virus (HTNV) may result in severe hemorrhagic fever with renal syndrome (HFRS). The functions of HLA-E-restricted CD8⁺ T lymphocytes in virus control and vaccine development have recently received increased attention. The purpose of this research is to discover HLA-E-restricted CD8⁺ T cell epitopes on HTNV as well as the features of these epitope-specific CD8⁺ T cells in HFRS patients. To anticipate HLA-E-restricted HTNV epitopes, the NetMHCpan servers were utilized. The K562/HLA-E cell binding test and the enzyme-linked immunospot assay were used to confirm epitope binding to HLA-E. The number and features of HLA-E-restricted epitope-specific CD8⁺ T lymphocytes in HFRS patients were investigated using tetramer staining

SUBMITTER: Tang K 

PROVIDER: S-EPMC11895001 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature