Differential T follicular helper cell phenotypes distinguish IgE-mediated milk allergy from eosinophilic esophagitis in children.

ABSTRACT:

Background

IgE-mediated food allergy and eosinophilic esophagitis (EoE) are diseases commonly triggered by milk. Milk-responsive CD4⁺ T cells producing type 2 cytokines are present in both diseases, yet the clinical manifestation of disease in milk allergy (MA) and EoE are distinct.

Objective

We sought to identify differences in CD4⁺ T cells between EoE and MA that may be responsible for distinct disease manifestations.

Method

The total and milk-specific CD4⁺ T-cell phenotype of children with MA, children with EoE (active or in remission), and controls was measured using spectral flow cytometry of peripheral blood (all groups) or esophageal biopsies (EoE and control).

Results

Circulating milk-responsive T cells could be identifi

SUBMITTER: Lozano-Ojalvo D 

PROVIDER: S-EPMC11895100 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature