Association of estimated small dense low-density lipoprotein cholesterol with diabetes mellitus: a large-scale multicenter retrospective cohort study.

ABSTRACT:

Background

Estimated small dense low-density lipoprotein cholesterol (sdLDL-C) was related to atherosclerosis, coronary heart disease and metabolic syndrome. Despite these findings, limited evidence is available on the relationship between sdLDL-C levels and the onset of diabetes mellitus (DM).

Methods

The study analyzed data from 118,080 adults enrolled at the Rich Healthcare Group between 2010 and 2016. The relationship between sdLDL-C levels and the risk of DM was examined using Cox proportional hazards regression. In order to evaluate potential nonlinear associations, cubic spline functions and smooth curve fitting were incorporated into the Cox regression framework. Furthermore, a two-piecewise Cox proportional hazards regression was employed to pinpoint the inflection

SUBMITTER: Gao Y 

PROVIDER: S-EPMC11895197 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature