Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells.

ABSTRACT:

Background

The regulation of chromatin accessibility is essential in eukaryotic cells as one of several mechanisms that ensure gene activation occurs at appropriate times and in appropriate cell types. Accordingly, mutations in chromatin remodeling proteins are linked to many different developmental disorders and cancers. One example of a chromatin protein that has been linked to both developmental abnormalities and cancer is BPTF/NURF301, the largest subunit of the Nucleosome Remodeling Factor (NuRF) complex. The BPTF subunit is not only important for the formation of NuRF but also helps direct its activity to particular regions of chromatin by preferentially binding histone H3 lysine four trimethylation (H3K4me3). Notably, defects caused by knockdown of bptf in Xenopus embryos mi

SUBMITTER: Verma P 

PROVIDER: S-EPMC11895202 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature