A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs.

ABSTRACT: Cerebrospinal fluid (CSF) plays a crucial role in maintaining brain homeostasis by facilitating the clearance of metabolic waste and regulating intracranial pressure. Dysregulation of CSF flow can lead to conditions like syringomyelia, and hydrocephalus. This review details the anatomy of CSF flow, examining its contribution to waste clearance within the brain and spinal cord. The review integrates data from human, canine, and other mammalian studies, with a particular focus on brachycephalic dogs. Certain dog breeds exhibit a high prevalence of CSF-related conditions due to artificial selection for neotenous traits, making them valuable models for studying analogous human conditions, such as Chiari-like malformation and syringomyelia associated with craniosynostosis. This review discusses

SUBMITTER: Jones R 

PROVIDER: S-EPMC11895204 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature