Disruption and adaptation: infant gut microbiota's dynamic response to SARS-CoV-2 infection.

ABSTRACT:

Background

The responses of the infant gut microbiota to infection significantly disrupt the natural intrahost evolutionary processes of the microbiome. Here, we collected a 16-month longitudinal cohort of infant gut microbiomes affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Then, we developed a multicriteria approach to identify core interaction network driving community dynamics under environmental disturbances, which we termed the Conserved Variated Interaction Group (CVIgroup).

Results

The CVIgroup showed significant advantages on pinpointing a sparse set associated with the disturbances, as validated both our own and publicly available datasets. Leveraging the Oxford Nanopore Technology, we found this group facilitates the ecosystem's adaptati

SUBMITTER: Zhu LT 

PROVIDER: S-EPMC11895207 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature