Comparison of hyaluronic acid and platelet-rich plasma in knee osteoarthritis: a systematic review.

ABSTRACT:

Background

Knee osteoarthritis (KOA) is a common joint disorder, and intra-articular injections of hyaluronic acid (HA) or platelet-rich plasma (PRP) are frequently employed therapeutic interventions. However, there remains controversy regarding their efficacy. This systematic review aims to compare the effectiveness and safety of HA and PRP through a meta-analysis, with the objective of identifying the optimal treatment protocol for KOA and enhancing its management.

Methods

Randomized controlled trials evaluating the clinical outcomes of patients receiving intra-articular injections of either HA or PRP were included as eligible studies. Two independent investigators assessed the selected studies and evaluated their risk of bias. Primary outcome measures included the Visual

SUBMITTER: Xu H 

PROVIDER: S-EPMC11895219 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature