Young fibroblast-derived migrasomes alleviate keratinocyte senescence and enhance wound healing in aged skin.

ABSTRACT:

Background

Alterations in intercellular communication driven by cellular senescence constitute an important factor in skin aging. Migrasome, a newly discovered vesicular organelle, efficiently participates in intercellular communication; however, the relationship between cellular senescence and migrasomes remains unreported.

Objective

This study aims to explore the possible relationship between cellular senescence and migrasomes formation, and investigate the effects of young fibroblast-derived migrasomes on senescent keratinocytes and wound healing in aged skin.

Result

Single-cell RNA sequencing (scRNA-seq) data analysis revealed that fibroblasts exhibited the highest level of transcriptional variability during skin aging, and the degree of fibroblast senescence nega

SUBMITTER: Tu H 

PROVIDER: S-EPMC11895310 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature