A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases.

ABSTRACT:

Background

Recent studies highlight the critical role of microglia in neurodegenerative disorders, and emphasize the need for humanized models to accurately study microglial responses. Human-mouse microglia xenotransplantation models are a valuable platform for functional studies and for testing therapeutic approaches, yet currently those models are only available for academic research. This hampers their implementation for the development and testing of medication that targets human microglia.

Methods

We developed the hCSF1^Bdes mouse line, which is suitable as a new transplantation model and available to be crossed to any disease model of interest. The hCSF1^Bdes model created by CRISPR gene editing is RAG2 deficient and expresses human CSF1. Additional

SUBMITTER: Serneels L 

PROVIDER: S-EPMC11895352 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature