The mediating role of the TyG index in the relationship between circadian syndrome and cancer among middle-aged and elderly Chinese.

ABSTRACT:

Background

Circadian Syndrome (CircS) is a significant marker of metabolic imbalance and has been linked to various chronic diseases. However, its relationship with cancer risk remains underexplored. This research aims to explore the relationship between CircS and cancer, while also assessing the possible mediating role of the triglyceride glucose (TyG) index.

Methods

Baseline data from the 2011 China Health and Retirement Longitudinal Study (CHARLS) and follow-up data from 2015 were analyzed, including participants' sociodemographic characteristics, health behaviors, and metabolic indicators. Linear regression, mediation analysis, and logistic regression were employed to explore relationships between CircS, cancer risk, and the TyG index, with a dose-response analysis condu

SUBMITTER: Bai Z 

PROVIDER: S-EPMC11895363 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature