Characterization and genomic analysis of Sharanji: a jumbo bacteriophage of Escherichia coli.

ABSTRACT:

Background

Bacteriophages are the most genetically diverse biological entities in nature. Our current understanding of phage biology primarily stems from studies on a limited number of model bacteriophages. Jumbo phages, characterized by their exceptionally large genomes, are less frequently isolated and studied. Some jumbo phages exhibit remarkable genetic diversity, unique infection mechanisms, and therapeutic potential.

Methods

In this study, we describe the isolation of Sharanji, a novel Escherichia coli jumbo phage, isolated from chicken feces. The phage genome was sequenced and analyzed extensively through gene annotation and phylogenetic analysis. The jumbo phage was phenotypically characterized through electron microscopy, host range analysis, and survival at differe

SUBMITTER: Magar S 

PROVIDER: S-EPMC11895373 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature