The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation.

ABSTRACT:

Background

Endothelial dysfunction is a hallmark feature of cardiovascular disease (CVD), yet the underlying mechanisms are still poorly understood. This has impeded the development of effective therapies, particularly for peripheral artery disease. FK506-binding protein like (FKBPL) and its therapeutic peptide mimetic, AD-01, are crucial negative regulators of angiogenesis, however their roles in CVD are unknown. In this study, we aimed to elucidate the FKBPL-mediated mechanisms involved in regulating endothelial dysfunction induced by hypoxia or inflammation, and to determine whether AD-01 can effectively restore endothelial function under these conditions.

Methods

Hindlimb ischemia was induced in mice by ligating the proximal and distal ends of the right femoral artery, a

SUBMITTER: Ghorbanpour S 

PROVIDER: S-EPMC11895374 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature