Changes in gene expression in healthcare workers during night shifts: implications for immune response and health risks.

ABSTRACT:

Background

Shift work is common in healthcare, especially in emergency and intensive care, to maintain the quality of patient care. Night shifts are linked to health risks such as cardiovascular disease, metabolic disorders, and poor mental health. It has been suggested that inflammatory responses due to the disruption of circadian rhythm may contribute to health risks, but the detailed mechanisms remain unclear. This study aimed to analyze changes in gene expression in whole blood of healthcare workers before and after a night shift and investigate the molecular pathogenesis of these changes and their impact on health.

Methods

This was a single-center, prospective, observational study of four medical doctors working night shifts in the emergency department. Blood samples fr

SUBMITTER: Nukiwa R 

PROVIDER: S-EPMC11895378 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature