Immunostimulatory effects of <i>Streptococcus sanguinis</i> extracellular membrane vesicles protect oral gingival epithelial cells from periodontal pathobiont damage.

ABSTRACT: The commensal Streptococcus sanguinis is highly prevalent in the oral cavity and characterized for its ability to inhibit growth of oral pathogens. Like many other cell types, streptococci produce extracellular membrane vesicles (EMVs), which contain specific molecular cargo and facilitate interactions with host cells. We previously demonstrated that EMVs from S. sanguinis are internalized by gingival epithelial cells (GECs) without causing cell death. Our aim is to characterize the effects of vesicles on eukaryotic cells. Microscopy studies of gingival epithelial cells inoculated with EMVs from wild-type and specific deletion mutants show differential uptake, with decreased uptake of ΔSSA1099 EMVs and increased uptake of ΔSSA1882 EMVs relative to SK36 EMVs. However, EMVs fro

SUBMITTER: Helliwell E 

PROVIDER: S-EPMC11895462 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature