Salivary Proteome Is Altered in Children With Small Area Thermal Burns.

ABSTRACT: Saliva is a child appropriate biofluid, but it has not previously been used to evaluate the systemic response to burn injury in children. The aim of this study was to investigate the salivary proteome of children with small area thermal skin burns relative to different burn characteristics (mechanism, time to re-epithelialization and risk of emotional distress). SWATH Mass Spectrometry was used to quantify the abundance of 742 proteins in the saliva of children with burns (n = 22) and healthy controls (n = 37). Eight proteins were differentially abundant in the saliva of children with burns compared to healthy children, and these were associated with immune processes, epidermal cell differentiation and transferrin receptor binding. Eleven proteins were differentially abundant in patients w

SUBMITTER: Carlton M 

PROVIDER: S-EPMC11895759 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature